Watch: First X-Men: Apocalypse Trailer

Oscar Isaac portrays the new villain in the action-packed sequel, centuries-old mutant En Sabah Nur (a.k.a. Apocalypse), who awakes to find that mutants are not living up to his satisfaction.

Recruiting Psylocke (Olivia Munn) and Magneto (Michael Fassbender) as part of his Four Horsemen crew to wipe out the world, he's ready to start over.

"Everything they built will fall," En Sabah Nur proclaims. "And from the ashes of their world, we'll build a better one.

"Has Charles Xavier (James McAvoy) even gone to the dark side? "I've never felt power like this before," Xavier exclaims.

So it's up to Mystique (Jennifer Lawrence) and Beast (Nicholas Hoult) to head up an army of young mutants. "That's why I'm here," she insists. "To fight!"

Don't miss: Cyclops (Tye Sheridan), Nightcrawler (Kodi Smit-McPhee), and Jean Grey (Sophie Turner). "The world needs the X-Men," Beast, as Hank McCoy, tells Mystique.

X-Men: Apocalypse is in theaters May 27, 2016.